N-Nitrosamine과 단순포진성 바이러스가 햄스터의 구강암 발생에 미치는 영향에 관한 실험적 연구
Combined Effect of N-Nitrosamines and Herpes Simplex Virus on Oral Carcinogenesis in Hamsters.
소속 상세정보
홍정표/Hong, J.P.
이재현/민병무/J. p Sapp/박노희/Lee, J.H./Min, B.M./Sapp, J.P./Park, N.H.
KMID : 0355219900150010125
Abstract
We have previously reported that simulated snuff dipping in conjunction with type 1 herpes simplex virus(HSV -1) induced oral malignant changes in hamsters. Present study was designed to investigate the carcinogenic effect of tobacco specific-N-nitrosamines(TSNAs) and type 1 f 1 c r pe s simplex virus(HSV -1), alone or in combination, in hamsters. Hamsters were divided into 6 groups and the right buccal pouch mucosa were treated as follows : Gyp 1, Control (Mock inoculation)[ MI] +Topical application [TA] of mineral oil [MO] : Grp 2, TA of 1 % N´- nitrosonornicotine [NNN]+IM : Grp3, TA of 1 % 4-N-nitrosomethylamino-l-(3-pyridyl)-1-butanone [NNK]+MI : Grp 4, HSV-1 inoculation [HI]+TA of MO : Grp 5, TA of 1% N- nitro sonornico tine [NNN]+HI : Grp6,TA of 1% NNK+HLTA of MO or TSNAs was initiated I day after the MI or HI and given 3 times per week for 20 consecutive weeks. At the end of the 30th week after the initiation of experiment, the animals were sacrificed and the buccal pouches were fixed for light microscopic examination. No ssnimals developed tumors or malignant histopathologic changes in the mucosa of the buccal pouches. These data indicate that individual TSNAs, alone or in conjunction with HSV-1 infection, do not develop malignant changes in hamster buccal pouches.virus type 1 in patients with oral cancer. Cancer 49, 2315-2320,1982.
26. Smith, H. G? Chretien, P. B., Henson, D. E., Silverman, N. A. and Alexander, J. C.
Viralspecific humoral immunity to herpes simplex-induced antigens in patients with squamous carcinoma of the head aad neck. Am. J. Surg., 132: 541-548,1976.
27. Duff, R. and Rapp, F. : Properties of hamster fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2. J. Virol., 8 : 469-47
7, 1971.
28. Li J. L., Jerkofsky M.A. and Rapp F. Demonstration of oncogenic potential of mammalian cells transformed by DNAcontaining viruses following photodynamic
inactivation. Int. J cancer, 15 : 190-202, 1975.
29. Jariwalla, R. J., Aurelian, L. and TS´O.P.O.P.
Tumorigenic transformation induced by a specific fragment of DNA from herpes simplex virus tpe 2. Proc. natn. Acad. Sci. U.S.A., 77: 2279--2t 83, 1980.
30. Wentz, W. B., Reagan, J. W., Heggie, A.D., Fu, Y.S. and Anthony, D.D. : Induction of uterine cancer with inactivated herpes simplex virus, types, I and 2. Cancer, 48
1783-1790,1981.
31. Hirch, J. M., Johansson, S. L. and Vahlne, A. : Effect of snuff and herpes simplex virus- 1 on rat oral mucosa : possible associations with the development of squamous cell carcinoma. J. oral Path, 13 : 52-62, 1984.
32. Hirsch, J. M., Svennerholm, B. and Vahine, A, : Inhibition of herpes simplex virus replication by tocacco extracts. Cancer Res? 44 : 1991-1997, 1984.
33. Brunnemann, K. D? Rivenson, A., Adams,
J. D? Hecht, S. S. and Hoffmann, D. : A
study of sunff carcinogenesis. LARD Sci.
Publ., 84 :456-459,1987.
34. Peacock, E. E., Greenberg, B. G. and Bra
wley, B. W. : The effect of snuff and tobacco
on the production of oral carcinoma : an experimental and epidemiological study. Ann. Surg., 151 : 542--550, 1960.
35. Pindborg, J. J., Reibel, J., Roed-Petersen, B. and Mehta, F. S., : Tobacco-induced changes in oral leukoplastic epithelium. Cancer, 45 : 2230-2336, 1980.
36. Winn, D. M., Blot, W. J., Shy, C. M., Pickle, L. W? Toledo, A. and Fraumeni, J. F. Jr.
Snuff dipping and oral cancer among women in the southern United States. New Engl. J. Med., 304 : 745-749. 1981.
37. Hoffmann, D. and Hecht, S. S. : Nicotine-derived N-Nitrosamines and tobaccorelated cancer, current status and future direction. Cancer Res., 45 : 935--944,1985.
38. Preston-Martin, S.: N-Nitroso compounds as a cause of human cancer. LARD Sci. Publ? 84 : 477--484, 1987.
39. Hecht, S. S? Rivenson, A., Braley, J., DiBello, J? Adams, J. D. and Hoffmann, D. Introduction of oral tumors in F344 rats by tobacco-specific nitrosamines and snuff. Cancer Res., 46 : 4162-4166, 1986.
40. Belinsky, S. A., White, C. M., Boucheron, J. A., Richardson, F. C., Swenberg, J. A. and Anderson, M. : Accumulation and persistence of DNA Adducts in respiratory
tissue of rats following multiple administ
ration of the tobacco -specific carcinogen
4-(methylnitrosamine) -1- (3-pyridyl) -1
butanone. Cancer Res., 46 : 1280-1284,
1986.
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